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p300 Acetyltransferase Is a Cytoplasm-to-Nucleus Shuttle for SMAD2/3 and TAZ Nuclear Transport in Transforming Growth Factor beta-Stimulated Hepatic Stellate Cells.
Wang Y, Tu K, Liu D, Guo L, Chen Y, Li Q, Maiers JL, Liu Z, Shah VH, Dou C, Tschumperlin D, Voneschen L, Yang R, Kang N. Wang Y, et al. Hepatology. 2019 Oct;70(4):1409-1423. doi: 10.1002/hep.30668. Epub 2019 May 23. Hepatology. 2019. PMID: 31004519 Free PMC article.
SMAD2/3 have multiple coactivators, including WW domain-containing transcription regulator protein 1 (WWTR1 or TAZ) and p300 acetyltransferase. In the nucleus, TAZ binds to SMAD2/3 to prevent SMAD2/3 nuclear export. However, how TAZ and SMAD2/3 …
SMAD2/3 have multiple coactivators, including WW domain-containing transcription regulator protein 1 (WWTR1 or TAZ) and p300 a …
YAP and TAZ are distinct effectors of corneal myofibroblast transformation.
Muppala S, Raghunathan VK, Jalilian I, Thomasy S, Murphy CJ. Muppala S, et al. Exp Eye Res. 2019 Mar;180:102-109. doi: 10.1016/j.exer.2018.12.009. Epub 2018 Dec 19. Exp Eye Res. 2019. PMID: 30578787 Free PMC article.
The expression of alpha-smooth muscle actin (alphaSMA), Smad 2, 3 and 4, CTGF and phospho-Smad2, 3, and 4 were assessed by qPCR and Western blotting. RESULTS: TGFbeta1 stimulation resulted in the decreased phosphorylation of YAP in the cytosol, and increased levels of phos …
The expression of alpha-smooth muscle actin (alphaSMA), Smad 2, 3 and 4, CTGF and phospho-Smad2, 3, and 4 were assessed by qPCR and W …
YAP/TAZ Are Essential for TGF-β2-Mediated Conjunctival Fibrosis.
Futakuchi A, Inoue T, Wei FY, Inoue-Mochita M, Fujimoto T, Tomizawa K, Tanihara H. Futakuchi A, et al. Invest Ophthalmol Vis Sci. 2018 Jun 1;59(7):3069-3078. doi: 10.1167/iovs.18-24258. Invest Ophthalmol Vis Sci. 2018. PMID: 30025139
RESULTS: TGF-beta2 stabilized YAP/TAZ and subsequently activated Smad2/3, which led to the transcription of fibrotic genes in human primary conjunctival fibroblasts. ...In contrast, CCN family proteins (CTGF and CYR61) depended on both YAP and TAZ. Mechanistically, YAP/TAZ …
RESULTS: TGF-beta2 stabilized YAP/TAZ and subsequently activated Smad2/3, which led to the transcription of fibrotic genes in human p …
Concurrent YAP/TAZ and SMAD signaling mediate vocal fold fibrosis.
Nakamura R, Hiwatashi N, Bing R, Doyle CP, Branski RC. Nakamura R, et al. Sci Rep. 2021 Jun 29;11(1):13484. doi: 10.1038/s41598-021-92871-z. Sci Rep. 2021. PMID: 34188130 Free PMC article.
Additionally, TGF-beta1 induced localization of YAP and TAZ in close proximity to SMAD2/3, and nuclear accumulation of SMAD2/3 was inhibited by a YAP/TAZ inhibitor. ...
Additionally, TGF-beta1 induced localization of YAP and TAZ in close proximity to SMAD2/3, and nuclear accumulation of SMAD2/3 …
Synergistic induction of CTGF by cytochalasin D and TGFbeta-1 in primary human renal epithelial cells: Role of transcriptional regulators MKL1, YAP/TAZ and Smad2/3.
Muehlich S, Rehm M, Ebenau A, Goppelt-Struebe M. Muehlich S, et al. Cell Signal. 2017 Jan;29:31-40. doi: 10.1016/j.cellsig.2016.10.002. Epub 2016 Oct 7. Cell Signal. 2017. PMID: 27721022
Preincubation with CytoD but not LatB synergistically enhanced the TGFbeta-1-stimulated synthesis of CTGF, both in cells cultured on plastic dishes as well as in polarized epithelial cells. CytoD had no direct effect on the phosphorylation of Smad2/3, but facilitated their …
Preincubation with CytoD but not LatB synergistically enhanced the TGFbeta-1-stimulated synthesis of CTGF, both in cells cultured on plastic …
TRPV4 regulates matrix stiffness and TGFβ1-induced epithelial-mesenchymal transition.
Sharma S, Goswami R, Zhang DX, Rahaman SO. Sharma S, et al. J Cell Mol Med. 2019 Feb;23(2):761-774. doi: 10.1111/jcmm.13972. Epub 2018 Nov 18. J Cell Mol Med. 2019. PMID: 30450767 Free PMC article.
Mechanistically, we found that: (a) TRPV4 was essential for the nuclear translocation of YAP/TAZ (yes-associated protein/transcriptional coactivator with PDZ-binding motif) in response to matrix stiffness and TGFbeta1, (b) TRPV4 deletion inhibited both matrix stiffness- and TGFbe …
Mechanistically, we found that: (a) TRPV4 was essential for the nuclear translocation of YAP/TAZ (yes-associated protein/transcriptional coa …
The Clinicopathological Significance of YAP/TAZ Expression in Hepatocellular Carcinoma with Relation to Hypoxia and Stemness.
Park H, Lee Y, Lee K, Lee H, Yoo JE, Ahn S, Park YN, Kim H. Park H, et al. Pathol Oncol Res. 2021 Mar 1;27:604600. doi: 10.3389/pore.2021.604600. eCollection 2021. Pathol Oncol Res. 2021. PMID: 34257565 Free PMC article.

YAP/TAZ-positive HCCs frequently demonstrated higher serum AFP levels, microvascular invasion, advanced tumor stage, increased proliferative activity and expression of stemness- and EMT-related markers, CAIX, p53 and Smad2/3 (p < 0.05, all). Interestingly, YAP/TAZ-posit

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YAP/TAZ-positive HCCs frequently demonstrated higher serum AFP levels, microvascular invasion, advanced tumor stage, increased proliferative …
TAZ promotes the proliferation and osteogenic differentiation of human periodontal ligament stem cells via the p-SMAD3.
Gu K, Fu X, Tian H, Zhang Y, Li A, Wang Y, Wen Y, Gu W. Gu K, et al. J Cell Biochem. 2020 Feb;121(2):1101-1113. doi: 10.1002/jcb.29346. Epub 2019 Sep 3. J Cell Biochem. 2020. PMID: 31478222
The molecular mechanism of TAZ in the promotion of h-PDLSC osteogenesis was also explored. The chemical inhibitor of SMAD2/3 SIS3 HCL was used to identify the effects in vitro osteogenic differentiation and bone formation in h-PDLSCs overexpressing TAZ. ...
The molecular mechanism of TAZ in the promotion of h-PDLSC osteogenesis was also explored. The chemical inhibitor of SMAD2/3 SIS3 HCL …